David’s research team apply systems immunology approaches to investigate how microbes (pathogenic and commensal) modulate the immune system in a range of contexts from infant immunisation to cancer immunotherapy. His research spans from computational modelling and bioinformatics software development to preclinical mouse models (including germ-free mice), to leading clinical studies. He also leads a NHMRC-funded systems vaccinology study to investigate the link between the microbiota and vaccine responses in infants. David is also the principal investigator in South Australia for the Gates Foundation-funded BRACE Trial, investigating whether BCG provides non-specific protection against COVID19. He has published 80+ peer-reviewed articles to date and in the last 10 years, and worked on projects worth over $20 million.